Predisposition
Are genes responsible for HIV infection/AIDS?

No.
In order to be able to infect cells, HIV needs the CD4 receptor and other ‘keys’, or coreceptors. One of these coreceptors is chemokine receptor 5 (CCR5). HIV uses this molecule, which is present on the surface of immune cells, as a ‘key’ to gain entry to the cell. HIV cannot infect cells whose surface does not contain CCR5. Studies have shown that individuals who lack the gene that codes for CCR5 develop AIDS two to four years later than would otherwise be the case.

© 2002-2009 F. Hoffmann-La Roche Ltd
See our Legal Statement