Modern Diagnostics
A new line of AmpliChip tests are designed to combine the power of the polymerase chain reaction (PCR) with the microarray technology. Microarrays are the recognised standard for the massively parallel study of genes within a biological system, including the study of gene structure and gene function. The Polymerase chain reaction is a technique used in molecular biology to amplify a single or few copies of a piece of DNA across several orders of magnitude, generating millions or more copies of the DNA piece.

AmpliChip CYP 450 Test
Often described as “molecular microscopes”, microarrays are powerful diagnostic and research tools packed onto tiny glass chips no bigger than a thumbnail. The AmpliChip CYP450 Test microarray contains more than 15’000 different oligonucleotide probes which can analyse both sense and anti-sense strands of an amplified target DNA sample. It is Roche’s first test to use microarray technology for comprehensive analysis of two genes that can influence drug efficacy and adverse drug reaction. The test detects genetic variations in the Cytochrome P450 2D6 and 2C19 genes and provides the associated predictive phenotype (poor, intermediate, extensive, or ultra-rapid metaboliser).