Bioengineered proteins are already being used to treat the following
diseases: - Hepatitis C: Pegylated (PEG) therapeutic protein. The
PEG barrier obstructs the protein breakdown machinery in the body’s cells and thereby prolongs the drug’s
duration of action.
- Renal anemia: A specially modified chemically synthesised protein
that stimulates red blood cell production.
Therapeutic antibodies form
a relatively new drug class that has only been made possible by modern biotechnology. Antibodies are
components of the immune system. They identify foreign structures in the body – e.g. molecules on the
surface of body cells, bacteria or viruses – and mark them out for elimination by the immune system.
There are several classes of antibodies, each of which has a different function. IgG antibodies
are the most abundant. These Y-shaped proteins bear two identical regions on their two short arms that
identify a specific foreign structure. The long stem of the molecule interacts with other components
of the immune system, which ultimately initiate destruction of the intruders. |